منابع مشابه
Spatial Control of Actin Filament Assembly Lessons from Listeria
the ability of cells to fix sites of actin assembly with The actin cytoskeleton of a eukaryotic cell is critical for a high degree of spatial resolution. For example, for many functions, including cell locomotion, cytokinesis, vectorial cell locomotion of a fibroblast to occur, actin intracellular transport, establishment of cell polarity, and assembly must be focused at the leading edge (Figur...
متن کاملA Correlative Analysis of Actin Filament Assembly, Structure, and Dynamics
The effect of the type of metal ion (i.e., Ca2+, Mg2+, or none) bound to the high-affinity divalent cation binding site (HAS) of actin on filament assembly, structure, and dynamics was investigated in the absence and presence of the mushroom toxin phalloidin. In agreement with earlier reports, we found the polymerization reaction of G-actin into F-actin filaments to be tightly controlled by the...
متن کاملCharacterization of Engineered Actin Binding Proteins That Control Filament Assembly and Structure
BACKGROUND Eukaryotic cells strictly regulate the structure and assembly of their actin filament networks in response to various stimuli. The actin binding proteins that control filament assembly are therefore attractive targets for those who wish to reorganize actin filaments and reengineer the cytoskeleton. Unfortunately, the naturally occurring actin binding proteins include only a limited s...
متن کاملTropomyosin diffusion over actin subunits facilitates thin filament assembly
Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that leads to continuous, gap-free tropomyosin cable formation. We propose that tropomyosin molecules diffuse over the actin-filament surface to co...
متن کاملPolylysine Induces an Antiparallel Actin Dimer That Nucleates Filament Assembly
From the Research Service, Malcom Randall Department of Veterans Affairs Medical Center and the University of Florida College of Medicine, Gainesville, Florida 32608, the ¶Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida 32610, the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, and the **In...
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ژورنال
عنوان ژورنال: Cell
سال: 1998
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81697-9